ЛЕЧЕНИЕ CАХАРНОГО ДИАБЕТА 2 ТИПА МЕТФОРМИНОМ И МЕТАБОЛИЗМ ВИТАМИНА В12
Аннотация
За последние 15 лет в диабетологии произошли революционные открытия в области исследований патогенеза СД2, сопровождающиеся развитием новых классов сахароснижающих препаратов, кардинально изменивших алгоритм лечения.
Библиографические ссылки
Alston TA. Does metformin interfere with thiamine? Arch Intern Med 2003; 163 (8): 983.
Xu L, Huang Z, He X et al. Adverse effect of metformin therapy on serum vitamin B12 and folate: short-term treatment causes disadvantages? Med Hypotheses 2013; 81 (2): 149–51.
Buvat DR. Use of metformin is a cause of vitamin B12 deficiency. Am Fam Physician 2004; 69 (2): 264; author reply 26.
Громова о.а., торшин и.ю., прокопович о.а. синергидные нейропротекторные эффекты тиамина, пиридоксина и цианокобаламина в рамках протеома человека. неврология и ревматология (прил. к журн. Consilium Medicum). 2016; 2: 76–84. / Gromova O.A., Torshin I.Yu., Prokopovich O.A. Synergistic neuroprotective effects of thiamine, pyridoxine and cyanocobalamin within the human proteome. Neurology and Rheumatology (Suppl. Consilium Medicum). 2016; 2: 76–84. [in Russian]
Adams JF, Clark JS, Ireland JT et al. Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy. Diabetologia 1983; 24 ((1): 16–8.
Muller P, Fischer H, Sorger D. Vitamin B12-level in serum of diabetics receiving long-term buformin therapy. Z Gesamte Inn Med 1981; 36 (6): 226–8.
Caspary WF, Zavada I, Reimold W et al. Alteration of bile acid metabolism and vitaminB12-absorption in diabetics on biguanides. Diabetologia 1977; 13 (3): 187–93.
маев и.в., самсонов а.а. Болезни двенадцатиперстной кишки. м.: медпресс-информ, 2005. / Maev I.V., Samsonov A.A. Bolezni dvenadtsatiperstnoi kishki. M.: MEDpress-inform, 2005. [in Russian]
Kapadia CR, Essandoh LK. Active absorption of vitamin B12 and conjugated bile salts by guinea pig ileum occurs in villous and not crypt cells. Dig Dis Sci 1988; 33 (11): 1377–82.
Tomkin GH. Comparison of the effect of parenteral with oral biguanide therapy on vitamin B12 and bile acid absorption. Ir J Med Sci 1976; 145 (1): 340.
Greibe E, Miller JW, Foutouhi SH et al. Metformin increases liver accumulation of vitamin B12 – an experimental study in rats. Biochimie 2013; 95 (5): 1062–5.
Obeid R, Jung J, Falk J et al. Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimie 2013; 95 (5): 1056–61.
Novelle M, Ali A, Diéguez C et al. Metformin: A Hopeful Promise in Aging Research. Cold Spring Harb Perspect Med 2016; 6 (3): a025932. DOI: 10.1101/cshperspect.a025932
Sahin M, Tutuncu NB, Ertugrul D et al. Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus. J Diabetes Complications 2007; 21 (2): 118–23.
Bauman WA, Shaw S, Jayatilleke E et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000; 23 (9): 1227–31.
Rufenacht P, Mach-Pascual S, Iten A. Vitamin B12 deficiency: a challenging diagnosis and treatment. Rev Med Suisse 2008; 4 (175): 2212–4, 2216–7.
Zdilla MJ. Metformin With Either Histamine H2-Receptor Antagonists or Proton Pump Inhibitors: A Polypharmacy Recipe for Neuropathy via Vitamin B12 Depletion. Clin Diabetes 2015; 33 (2): 90–5.
Damiao CP, Rodrigues AO, Pinheiro MF et al. Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study. Sao Paulo Med J 2016; 134 (6): 473–9.
Roy RP, Ghosh K, Ghosh M et al. Study of Vitamin B12 deficiency and peripheral neuropathy in metformin-treated early Type 2 diabetes mellitus. Indian J Endocrinol Metab 2016;
(5): 631–7. 20. Andres E, Perrin AE, Demangeat C et al. The syndrome of food-cobalamin malabsorption revisited in a department of internal medicine. A monocentric cohort study of 80 patients. Eur J Intern Med 2003; 14 (4): 221–6.
Hansen CS, Jensen JS, Ridderstrale M et al. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes. J Diabetes Complications 2017; 31 (1): 202–8. 22. Moore E, Mander A, Ames D et al. Cognitive impairment and vitamin B12: a review. Int Psychogeriatr 2012; 24 (4): 541–56.
Mourits-Andersen T, Ditzel J. Megaloblastic anemia caused by malabsorption of vitamin B12 during long-term metformin therapy. Ugeskr Laeger 1983; 145 (1): 25–6.
Callaghan TS, Hadden DR, Tomkin GH. Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment. Br Med J 1980; 280 (6225): 1214–5.
Biemans E, Hart HE, Rutten GE et al. Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin. Acta Diabetol 2015; 52 (2): 383–93.
Ahmed MA, Muntingh G, Rheeder P. Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy. BMC Pharmacol Toxicol 2016; 17 (1): 44.
Damiao CP, Rodrigues AO, Pinheiro MF et al. Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study. Sao Paulo Med J 2016; Sao Paulo: S1516-318020160050.
Wulffele MG, Kooy A, Lehert P et al. Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med 2003; 254 (5): 455–63.
Kancherla V, Garn JV, Zakai NA et al. Multivitamin Use and Serum Vitamin B12 Concentrations in Older-Adult Metformin Users in REGARDS, 2003–2007. PLoS One 2016; 11 (8): e0160802.
Chapman LE, Darling AL, Brown JE. Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Metab 2016; 42 (5): 316–27.
Holmes D. Diabetes: Metformin linked to vitamin B12 deficiency. Nat Rev Endocrinol 2016; 12 (6): 312.
Aroda VR, Edelstein SL, Goldberg RB et al. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab 2016; 101 (4): 1754–61.
Liu Q, Li S, Quan H, Li J. Vitamin B12 status in metformin treated patients: systematic review. PLoS One 2014; 9 (6): e100379.
Niafar M, Hai F, Porhomayon J, Nader ND. The role of metformin on vitamin B12 deficiency: a meta-analysis review. Intern Emerg Med 2015; 10 (1): 93–102. O.A.Gromova et al. / Consilium Medicum. 2017; 19 (4): 58–64.
Parry-Strong A, Langdana F, Haeusler S et al. Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomised trial. N Z Med J 2016; 129 (1436): 67–75.
Beulens JW, Hart HE, Kuijs R et al. Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. Acta Diabetol 2015; 52 (1): 47–53.
Доскина е.в. диабетическая полинейропатия и в12-дефицитные состояния: основы патогенеза, пути лечения и профилактики. Фарматека. 2011; 20: 38–43. / Doskina E.V. Diabeticheskaia polineiropatiia i B12-defitsitnye sostoianiia: osnovy patogeneza, puti lecheniia i profilaktiki. Farmateka. 2011; 20: 38–43. [in Russian]
Панкратова ю.в. длительное лечение метформином пациентов с сахарным диабетом 2 типа и витамин в12: рандомизированное плацебо-контролируемое исследование. ожирение и метаболизм. 2012; 4: 56–7. /
Клинические рекомендации по лечению сахарного диабета 2 типа. 2019 г. Ташкент
