PROTON POMPASI INGIBITORLARINING JIGAR SIRROZI BILAN OG’RIGAN BEMORLARNING RUHIY HOLATIGA TA'SIRI
Ключевые слова:
jigar ensefalopatiyasi, ichak mikrobiomasi, jigar sirrozi, gastropatiya, proton pompasi ingibitorlari.Аннотация
So’nggi vaqtda surunkali jigar kasalliklari ko'plab rivojlangan mamlakatlarda o'limning eng keng tarqalgan sababi sifatida etakchi o'rinni egallamoqda. Jigar yetishmovchiligini keltirib chiqaradigan sabablardan biri jigar ensefalopatiyasi (JE) sindromi bo'lib, u miya faoliyatining kognitiv buzilishlarning minimal darajasidan tortib komagacha bo'lgan keng doiradagi nevrologik yoki psixologik buzilishlar bilan namoyon bo'ladigan belgilar majmuasidir. JE sabablari ilmiy tadqiqotchilar tomonidan atroflicha o’rganilgan, ammo shunday holatlar ham borki, dori vositalarining o’zi ham JE keltirib chiqarishi mumkin. Tadqiqotchilar jigar sirrozida Proton pompasi ingibitorlaridan (PPI) foydalanish ichak bakteriyalarida miqdoriy va sifatiy o’zgarish keltirib chiqarishi va ichaklarda patogen bakteriyalar ko'payganda ammiak ishlab chiqarilishi oshib jigar ensefalopatiyasini keltirib chiqarishi va/yoki mavjud JEni bosqichini yomonlashtirishi mumkinligi haqida dalillarni topdilar.
Библиографические ссылки
Bajaj JS, Ratliff SM, Heuman DM, et al. Proton pump inhibitors are associated with a high rate of serious infections in veterans with decompensated cirrhosis. Aliment Pharmacol Ther 2012;36:866–74.
Bekmuradova M. S., Bozorova S. A. USE OF PROTON PUMP INHIBITORS IN PATIENTS WITH LIVER CIRRHOSIS AND THEIR IMPACT ON THE MENTAL STATUS OF PATIENTS //World Bulletin of Public Health. – 2023. – Т. 29. – С. 75-79.
Bekmuradova M. S., Shodieva G. R. Helicobacter pylori worsening factor of the patient's condition in patients with liver encephalopathy. – 2021.
Bian J, Wang A, Lin J, Wu L, Huang H, Wang S, Yang X, Lu X, Xu Y, Zhao H. Association between proton pump inhibitors and hepatic encephalopathy: A meta-analysis. Medicine (Baltimore). 2017.
Bian J, Wang A, Lin J, Wu L, Huang H, Wang S, Yang X, Lu X, Xu Y, Zhao H. Association between proton pump inhibitors and hepatic encephalopathy: A meta-analysis. Medicine (Baltimore). 2017 Apr;96(17).
Dam G, Vilstrup H, Watson H, et al. Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites. Hepatology 2016;64:1265–72. a patient // UJCR. 2021. №1. URL:
Fasullo M, Rau P, Liu DQ, Holzwanger E, Mathew JP, Guilarte-Walker Y, Szabo G. Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients. World J Hepatol. 2019 Jun 27;11(6):522-530. doi: 10.4254/wjh.v11.i6.522. PMID: 31293720; PMCID: PMC6603505.
Jackson MA, Goodrich JK, Maxan ME, et al. Proton pump inhibitors alter the composition of the gut microbiota. Gut 2016; 65:749-56.
Khabibovna Y. S., Salkhidinovna B. M. Effects of proton pump inhibitors on hepatic encephalopathy in patients with cirrhosis //World Bulletin of Public Health. – 2022. – Т. 9. – С. 230-233.
Min YW, Lim KS, Min BH, et al. Proton pump inhibitor use significantly increases the risk of spontaneous bacterial peritonitis in 1965 patients with cirrhosis and ascites: a propensity score matched cohort study. Aliment Pharmacol Ther 2014;40:695–704.
Quigley EM, Stanton C, Murphy EF. The gut microbiota and the liver. Pathophysiological and clinical implications. J Hepatol 2013;58:1020–7. [pubmed] [Google Scholar]
Salhiddinovna, B. M. ., Alisherovna , K. M. ., Tashtemirovna , E. M. ., & Tatlibayevich, Y. S. . (2023). Hepatic Encephalopathy and Quality of Life of Patients With Viral Cirrhosis of the Liver. Miasto Przyszłości, 35, 1–5.
Salkhidinovna B. M., Rabimkulovna S. G., Totliboevich Y. S. Comparative assessment of the effect of omeprazole and pantaprazole on the degree of development of hepatic encephalopathy in the patients with liver cirrhosis //E-Conference Globe. – 2021. – С. 149-152.
Tsung-Hsing Hung, Hsing-Feng Lee, Chih-Wei Tseng, Chih-Chun Tsai, Chen-Chi Tsai. Effect of proton pump inhibitors in hospitalization on mortality of patients with hepatic encephalopathy and cirrhosis but no active gastrointestinal bleeding, Clinics and Research in Hepatology and Gastroenterology, Volume 42, Issue 4, 2018, 353-359.
Vilstrup H., Amodio P., Bajaj J. Et al. Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the American association for the study of liver diseases and the European association for the study of the liver. Hepatology. 2014; 60: 715–735.
Wehmeyer MH, Horvatits T, Buchholz A, Krause L, Walter S, Zapf A, Lohse AW, Kluwe J; STOPPIT-trial group. Stop of proton-pump inhibitor treatment in patients with liver cirrhosis (STOPPIT): study protocol for a prospective, multicentre, controlled, randomized, double-blind trial. Trials. 2022 Apr 12;23(1):302.
Weissenborn K, Ennen JC, Schomerus H, et al. Neuropsychological characterization of hepatic encephalopathy. J Hepatol 2001;34:768–73.
Yang YX, Lewis JD, Epstein S, et al. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA 2006;296:2947–53.
Ziyadullaev Shukhrat Khudoyberdievich, Bekmuradova Makhsuda Salkhidinovna, Toirov Doston Rustamovich, Effect of Proton Pump Inhibitors on Hepatic Encephalopathy in Cirrhotic Patients with Concomitant Gastroduodenal Disorders, American Journal of Medicine and Medical Sciences, Vol. 13 No. 2, 2023, pp. 112-118. Doi: 10.5923/j.ajmms.20231302.18.
Бекмурадова М. С. Влияние ингибиторов протонной помпы на печеночную энцефалопатию у пациентов циррозом печени сопутствующей гастродуоденальной патологией //Science and Education. – 2022. – Т. 3. – №. 12. – С. 280-287.
Бекмурадова М. С., Гаффаров Х. Х., Ярматов С. Т. Ошқозон-ичак тракти зарарланиши устунлиги билан кечган коронавирус инфекциясидан кейинги ҳолатни даволашнинг ўзига хосликлари //Scientific progress. – 2021. – Т. 2. – №. 1. – С. 489-493.
Бекмурадова М. С., Норматов М. Б. Сравнительная оценка динамики печеночной энцефалопатии у больных с циррозом печени //Scientific progress. – 2022. – Т. 3. – №. 2. – С. 895-899.
Бекмурадова м. С., Шарипова з. Ш., Шодиева г. Р. Uzbek journal of case reports //uzbek journal of case reports Учредители: Самаркандский государственный медицинский институт. – 2021. – Т. 1. – №. 1. – С. 12-14.
Ивашкин В.Т., Маевская М.В., Павлов Ч.С., Федосьина Е.А., Бессонова Е.Н., Пирогова И.Ю., Гарбузенко Д.В. Клинические рекомендации Российского общества по изучению печени и Российской гастроэнтерологической ассоциации по лечению осложнений цирроза печени. Рос.журнал гастроэнтерологов, гепатологов, колопроктологов. 2016; 26(4): 71–102.
Максимова Е.В., Кляритская И.Л. «Печеночная энцефалопатия, диагностика, дифференциальная диагностика и терапия при помощи орнитина» 2018. Ст. 110-116.
Моисеева Е.О. «Современные клинические и инструментальные методы диагностики печеночной энцефалопатии». Вестник Смоленской государственной медицинской академии. 2010.78-83.
