PROTON POMPASI INGIBITORLARINING JIGAR SIRROZI BILAN OG’RIGAN BEMORLARNING RUHIY HOLATIGA TA'SIRI
Keywords:
jigar ensefalopatiyasi, ichak mikrobiomasi, jigar sirrozi, gastropatiya, proton pompasi ingibitorlari.Abstract
So’nggi vaqtda surunkali jigar kasalliklari ko'plab rivojlangan mamlakatlarda o'limning eng keng tarqalgan sababi sifatida etakchi o'rinni egallamoqda. Jigar yetishmovchiligini keltirib chiqaradigan sabablardan biri jigar ensefalopatiyasi (JE) sindromi bo'lib, u miya faoliyatining kognitiv buzilishlarning minimal darajasidan tortib komagacha bo'lgan keng doiradagi nevrologik yoki psixologik buzilishlar bilan namoyon bo'ladigan belgilar majmuasidir. JE sabablari ilmiy tadqiqotchilar tomonidan atroflicha o’rganilgan, ammo shunday holatlar ham borki, dori vositalarining o’zi ham JE keltirib chiqarishi mumkin. Tadqiqotchilar jigar sirrozida Proton pompasi ingibitorlaridan (PPI) foydalanish ichak bakteriyalarida miqdoriy va sifatiy o’zgarish keltirib chiqarishi va ichaklarda patogen bakteriyalar ko'payganda ammiak ishlab chiqarilishi oshib jigar ensefalopatiyasini keltirib chiqarishi va/yoki mavjud JEni bosqichini yomonlashtirishi mumkinligi haqida dalillarni topdilar.
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