COVID-19 БИЛАН КАСАЛЛАНГАН ЎЗБЕК БЕМОРЛАРИДА, КАСАЛЛИКНИНГ ОҒИРЛИК ДАРАЖАСИ ВА ГОМОЦИСТЕИН КОНЦЕНТРАЦИЯСИГА MTR ГЕНИ rs1805087, MTRR ГЕНИ rs1801394 ПОЛИМОРФИЗМЛАРИНИНГ БОҒЛИҚЛИГИ
Ключевые слова:
MTR, MTRR, rs1805087, rs1801394, ёввойи аллел, минор аллел фолат цикли, гипергомоцистеинемия, эндотелиал дисфункция.Аннотация
SARS-CoV-2 инфекцияси кўзғатган COVID-19 нинг энг оғир асоратларидан бири, гиперкоагулопатия индуцирлаган хаётий мухим органларни ишемик бузилиши хисобланиб, у сабабли COVID-19 билан касалланган беморларда ногиронлик ва ўлим холатлари кўплаб кузатилмоқда. Шу сабабли, гиперкоагулопатияга сабабчи бўлувчи факторларни чуқур ўрганиш орқали, бу паталогик жараёни ривожланишига мойиллиги бор беморларни саралаб олиб уларда махсус пролифактив ва терапевтик амалиётлар ўтказиш орқали юқорида келтирилган мажрухлик ва ўлим кўрсаткичларини камайтириш мумкин. Гиперкоагулопатияга сабаб бўлувчифакторлардан бири, бу тромбофил генлар хисобланганMTR ва MTRR генларини полиморфизмлари бўлиб, уларни COVID-19 билан касалланган ўзбек беморларида ўрганиш, бу генларнинг турли аллеларини шу ўрганилган беморларда гомоцистеин миқдорига ўзаро боғлиқлиги, хамда COVID-19 патогенезидаги қандай ахамиятга эга эканлигини тушунишга ёрдам бериши мумкин.
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