MORPHOMETRIC FEATURES OF MESANGIOPROLIFERATIVE GLOMERULONEPHRITIS WITH NEPHROTIC SYNDROME AND CORRELATION OF MORPHO-LABORATORY PARAMETERS
Keywords:
nephrotic syndrome, a morphological form of glomerulonephritis.Abstract
The results of biopsies obtained from patients with nephrotic syndrome were stu-died. Necessary material for research was collected from patients, who were on treat-ment and the nephrological department of the 1st polyclinic MHRUz. A compre-hensive clinical and laboratory examination was performed on 104 patients. Of these, 58 had a proteinuric form of chronic glomerulonephritis. The mean age of the patients was 24.9±5.2 years. Depending on the morphological variant of glomerulonephritis, all patients were divided into 5 groups. The data from the correlation analysis of the studied morphometric parameters and the data of routine laboratory studies made it possible to create a mathematical model that can be used to determine the morpho-logical form of chronic glomerulonephritis.
References
West G.D. Childhood membrano proliferative glomerulonefritis: An approach to management.// Kidney Int.-1986..-Vol. 29 № 8.-P. 1077-1093.
Schmit H., Bohle A. Tubulointerstitial alternations in type I membranoproliferative glomerulonephritis. An investigation of 259 cases.// Path. Res. Pract. 1987.-Vol.182, №1-P.6-10.
Peruzzi L., et al. Tubulointerstitial responses in the рrogression of glomerular disseases: albuminuria modulates alpha-beta 5 integrin. Kidney Int. 1996 Oct; 50(4)1310-20.
Mactier R., et al. The natural History of embranous nephropathy in the west skotland.// Quart J. Med., New Sep.-1981.-Vol.60, № 232.-P.946-956.
Honkanen E. et al. Membranous glomerulonephritis in rheumatoid arthritis not related to goldor d-penicilamine therapy: a report of four cases and review of the literature.//Clin. Nephrol. -1986.-Vol.18. № 2.-P. 87-93.
Zucchelli P., Cagnoli L., Pasquali S et al. Clinical and morphologic evolution idiopathic membranous efropathy.// Clin Nephrol.- 1986.- Vol. 25.
Beck LH, Bonegio RG, Lambeau G. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361(1):11, 2009. doi: 10.1056/NEJMoa0810457
Fervenza FC, Appel GB, BarbourSJ, et al: Rituximab or cyclosporine in the treatment of membranous nephropathy. N Engl J Med 381(1):36-46, 2019. doi: 10.1056/NEJMoa1814427
Ronco P, Debiec H. Molecular pathogenesis of membranous nephropathy. Annu Rev Pathol Mech Dis. 2020. 15:287–313 2.
Alsharhan L, Beck LH. Membranous Nephropathy: Core Curriculum 2021. Am J Kidne Dis. 2020; XX(XX):1-14. doi:10.1053/j.ajkd.2020.10.009 3.
Xu Z, Chen L, Xiang H et al. Advances in Pathogenesis of Idiopathic Membranous Nephropathy. Kidney Dis. 2020 Sep 6(5): 330-345. doi: 10.1159/00050770
Yuldashev, G., Urmanov, S., & Isagaliev, M. (2014). Biogeochemistry of mercury of mountain cinnamonic soils of the south of Ferghana. Europaische Fachhochschule, (5), 3-6.
