VITAMIN B12 METABOLIZMI, YETISHMOVCHILIGINING KLINIK NAMOYONI
Keywords:
tcianokobalamin, qandli diabet, vitamin B12, holesterin, lipid spektr, metformin, inssulinrezistentlik, semizlik, tana vazni oshiqligiAbstract
Vitamin B12 – bu vitamin faollikka ega bo’lgan kobalamin molekulalarining ikki kimyoviy shaklining - tcianokobalamin va gidrokikobalamini umumiy nomidir. Bu ikki hakl organizmda faol birikmaga - metilkobalamin va adenozilkobalaminga aylanib, aynan faol shaklda Vitamin B12 o’z fiziologik vazifasini bajaradi. Vitamin B12 ahamiyati – qon hosil bo;lishida ( gemopoetik hujayralar shakllanishi, neyroprotektor va neyrotrofik effeekt, yog’lar, mikronutrientlar metabolizmiga katta ta’siri bordir. Shuni takidlash kerakki Vitamin B12 yetishmovchilik holatlari metformin preparatini uzoqroq vaqt qabul qilish bilan ham bog’liqdir.
Metformin qandli diabet 2 turini davolashda qo’llaniladigan asosiy biguanidlar guruhiga mansub preparatiir, qonda qand miqdorini pasaytiradi, insulinorezistentlikka qarshi ta’sirga ega, qon tomir patologiyasi va o'lim xavfini kamaytiradi, geroprotektiv ta'sir ko'rsatadi. Epidemiologik va randomizatsiyalangan tadqiqotlar shuni ko'rsatdiki, metformin bilan uzoq muddatli davolanish qonda B12 vitamini darajasining pasayishi xavfini oshiradi, bu diabetik periferik neyropatiyaning rivojlanishiga ta’sir etadi. Metformin qabul qiliish miqdori va davomiyligi katta ahamiyatga egadir.
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